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Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen
Author(s) -
Zhang Le,
Li Feng,
Dimayuga Edgardo,
Craddock Jeffrey,
Keller Jeffrey N.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.10.054
Subject(s) - sumo protein , proteasome , ubiquitin , spleen , microbiology and biotechnology , proteolysis , biology , biochemistry , immunology , enzyme , gene
In the present study, we demonstrate for the first time that aging increases the levels of ubiquitinated protein in the spleen, and that dietary restriction (DR) significantly reduces these age‐related increases in ubiquitinated protein. Sumoylated protein, proteasome subunits, and a protein essential for proteasome biogenesis (POMP1) were also increased with age in the spleen but were not significantly affected by DR. Chymotrypsin‐like proteasome activity was elevated in the aged spleen, and was not significantly altered by DR. Together, these data demonstrate for the first time the multiple effects of aging and DR on ubiquitination, sumoylation, and the proteasome in the spleen.