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Anti‐obesity and anti‐tumor pro‐apoptotic peptides are sufficient to cause release of cytochrome c from vesicles
Author(s) -
Sandoval Cristina M.,
Salzameda Bridget,
Reyes Kristine,
Williams Taylor,
Hohman Valerie S.,
Plesniak Leigh A.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.10.051
Subject(s) - vesicle , peptide , cytochrome c , lysis , apoptosis , chemistry , cell , mitochondrion , microbiology and biotechnology , cytochrome , membrane , biophysics , receptor , cell membrane , programmed cell death , biochemistry , biology , enzyme
Peptides that target tissue for an apoptotic death have potential as therapeutics in a variety of disease conditions. The class of peptides described herein enters the cell through a specific receptor‐mediated interaction. Once inside the cell, the peptide migrates toward the mitochondria, where the membrane barrier is disrupted. These experiments demonstrate that upon treatment with these short peptides large unilamellar vesicles are not lysed, a graded mode of leakage is observed and the transient pores formed by these peptides are large enough to release entrapped cytochrome c from the vesicles.