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TLR‐ and NOD2‐dependent regulation of human phagocyte‐specific chitotriosidase
Author(s) -
van Eijk Marco,
Scheij Saskia S.,
van Roomen Cindy P.A.A.,
Speijer Dave,
Boot Rolf G.,
Aerts Johannes M.F.G.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.10.039
Subject(s) - phagocyte , nod2 , innate immune system , biology , microbiology and biotechnology , phagocytosis , in vitro , macrophage , receptor , in vivo , tlr4 , nod , chemistry , biochemistry , signal transduction , genetics
Human chitotriosidase is specifically expressed by phagocytes, has anti‐fungal activity towards chitin‐containing fungi in vitro and in vivo, and is part of innate immunity. We studied the effect of toll‐like receptor (TLR)‐ and nucleotide‐binding oligomerization domain (NOD)‐2 triggering on chitotriosidase expression and release by phagocytes. We find that TLR, but not NOD2 activation, regulates chitotriosidase release by neutrophils. Furthermore, both TLR and NOD2 activation resulted in diminished induction by monocytes. Lastly, NOD2 activation, but not TLR stimulation, induces chitinase expression in macrophages. We conclude that phagocyte‐specific regulation is important for efficient eradication of chitin‐containing pathogens.