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Phylogenetic and evolutionary analysis of the septin protein family in metazoan
Author(s) -
Cao Lihuan,
Ding Xiangming,
Yu Wenbo,
Yang Xianmei,
Shen Suqin,
Yu Long
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.10.032
Subject(s) - septin , biology , phylogenetic tree , ciona intestinalis , gene , vertebrate , genetics , phylogenetics , gene family , lineage (genetic) , gene duplication , evolutionary biology , molecular evolution , chordate , genome , cytokinesis , cell division , cell
Septins, a conserved family of cytoskeletal GTP‐binding proteins, were presented in diverse eukaryotes. Here, a comprehensive phylogenetic and evolutionary analysis for septin proteins in metazoan was carried out. First, we demonstrated that all septin proteins in metazoan could be clustered into four subgroups, and the representative homologue of every subgroup was presented in the non‐vertebrate chordate Ciona intestinalis , indicating that the emergence of the four septin subgroups should have occurred prior to divergence of vertebrates and invertebrates, and the expansion of the septin gene number in vertebrates was mainly by the duplication of pre‐existing genes rather than by the appearance of new septin subgroup. Second, the direct orthologues of most human septins existed in zebrafish, which suggested that human septin gene repertoire was mainly formed by as far as before the split between fishes and land vertebrates. Third, we found that the evolutionary rate within septin family in mammalian lineage varies significantly, human SEPT1, SEPT 10, SEPT 12, and SEPT 14 displayed a relative elevated evolutionary rate compared with other septin members. Our data will provide new insights for the further function study of this protein family.