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TGF‐β suppresses POEM expression through ERK1/2 and JNK in osteoblasts
Author(s) -
Miyazono Agasa,
Yamada Atsushi,
Morimura Naoko,
Takami Masamichi,
Suzuki Dai,
Kobayashi Makoto,
Tezuka Ken-ichi,
Yamamoto Matsuo,
Kamijo Ryutaro
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.10.021
Subject(s) - extracellular , extracellular matrix , kinase , signal transduction , microbiology and biotechnology , transforming growth factor , chemistry , transforming growth factor beta , gene expression , phosphorylation , gene , biology , biochemistry
POEM, also called nephronectin, is an extracellular matrix protein that is considered to play a critical role as an adhesion molecule in the development and functioning of various tissues, such as kidneys and bones. In the present study, we examined the molecular mechanism of POEM gene expression, and found that transforming growth factor‐β (TGF‐β) strongly inhibited POEM expression in the mouse osteoblastic cell line, MC3T3‐E1. TGF‐β‐induced decrease of POEM expression occurred in both time‐ and dose‐dependent manners through the activation of TGF‐β receptor I and extracellular signal‐regulated kinase/c‐Jun N‐terminal kinase pathways.