Premium
Pioneer round of translation mediated by nuclear cap‐binding proteins CBP80/20 occurs during prolonged hypoxia
Author(s) -
Oh Nara,
Kim Kyoung Mi,
Choe Junho,
Kim Yoon Ki
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.10.002
Subject(s) - nonsense mediated decay , translation (biology) , messenger rna , hypoxia (environmental) , protein biosynthesis , microbiology and biotechnology , biology , chemistry , rna , biochemistry , gene , oxygen , rna splicing , organic chemistry
Nonsense‐mediated mRNA decay (NMD) is one of the mRNA surveillance mechanisms, which eliminates aberrant mRNAs harboring premature termination codons. NMD targets only mRNAs bound by the nuclear cap‐binding protein complex CBP80/20 which directs the pioneer round of translation. Here we demonstrate that NMD occurs efficiently during prolonged hypoxia in which steady‐state translation is drastically inhibited. Accordingly, CBP80 remains in the nucleus, and processing bodies are unaffected with regard to their abundance and number under prolonged hypoxic conditions. These results indicate that mRNAs enter the pioneer round of translation during prolonged hypoxia.