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Oleic acid: An efficient inhibitor of glucosyltransferase
Author(s) -
Won Se-Ra,
Hong Mi-Jung,
Kim Yong-Mu,
Li Chun Ying,
Kim Jang-Won,
Rhee Hae-Ik
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.09.045
Subject(s) - oleic acid , glucosyltransferase , chemistry , fatty acid , biochemistry , enzyme
Among the extracts from 420 kinds of herbs, Prunus salicina , showing the highest glucosyltransferase inhibition activity, was purified and designated GTI‐0163. Structural determination of GTI‐0163 revealed it to be an oleic acid‐based unsaturated fatty acid. GTI‐0163 was an uncompetitive inhibitor of GTase. Among the unsaturated fatty acids, oleic acid showed a significantly higher GTase inhibitory activity than the saturated fatty acids or the ester form of oleic acid. These results strongly suggested that both the number of double bonds and the existence of free carboxyl groups of fatty acids play an important role in GTase inhibitory activity.