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A novel ovary‐specific and ovulation‐associated variant of epoxide hydrolase 2
Author(s) -
Shkolnik Ketty,
Ben-Dor Shifra,
Galiani Dalia,
Hourvitz Ariel,
Dekel Nava
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.09.016
Subject(s) - ovulation , ovary , luteinizing hormone , epoxide hydrolase , gene isoform , protein kinase a , chemistry , kinase , medicine , endocrinology , biology , microbiology and biotechnology , enzyme , gene , hormone , biochemistry , microsome
Ovulation is a complex process initiated by the surge of the pituitary luteinizing hormone (LH) that provokes the expression of specific genes. We report herein the isolation and characterization of an ovulation‐associated, ovary‐specific novel isoform of epoxide hydrolase 2 (Ephx2), Ephx2C. This variant is exclusively expressed in the granulosa cells of preovulatory mouse ovarian follicles. The LH‐induced expression of Ephx2C is mediated by the protein kinase A and partially by the protein kinase C signaling pathways. The involvement of p38 kinase has also been demonstrated.