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Resistin induces lipolysis and re‐esterification of triacylglycerol stores, and increases cholesteryl ester deposition, in human macrophages
Author(s) -
Rae Colin,
Robertson Stephanie A.,
Taylor Janice M.W.,
Graham Annette
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.09.014
Subject(s) - lipolysis , cholesteryl ester , chemistry , resistin , endocrinology , medicine , sterol o acyltransferase , foam cell , biochemistry , acetyl coa carboxylase , macrophage , atheroma , cholesterol , adipose tissue , lipoprotein , biology , pyruvate carboxylase , enzyme , insulin resistance , adiponectin , obesity , in vitro
Human resistin, found within atheroma, exerts inflammatory, angiogenic and proliferative effects in vascular cells and may predict coronary events. Here, we investigate mechanisms by which resistin contributes to macrophage ‘foam cell’ formation. Increases in macrophage (THP‐1) cholesteryl ester mass, in the presence or absence of oxidized LDL, were not explained by altered cholesterol efflux. Instead, resistin enhanced fractional turnover of the endogenous triacylglycerol pool, increased uptake and decreased oxidation of exogenous fatty acids, and decreased phosphorylation of acetyl CoA carboxylase, all factors increasing the availability of fatty acyl CoA substrate for acyl CoA: cholesterol acyltransferase‐1, thereby enhancing macrophage cholesteryl ester deposition.