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Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin β is the true human homologue of rat thymosin β15
Author(s) -
Dhaese S.,
Jonckheere V.,
Goethals M.,
Waltregny D.,
Vandekerckhove J.,
Ampe C.,
Van Troys M.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.09.003
Subject(s) - thymosin , neuroblastoma , prostate cancer , gene isoform , downregulation and upregulation , cancer research , biology , peptide , cancer , cell culture , microbiology and biotechnology , chemistry , biochemistry , gene , genetics
A peptide with a sequence identical to rat thymosin β(Tb)15 was reported to be upregulated in human prostate cancer. However, in this report we provide evidence that TbNB, initially identified in human neuroblastoma, is the only Tb isoform upregulated in human prostate cancer and that the Tb15 sequence is not present herein. In addition, we demonstrate that human TbNB has a higher affinity for actin in comparison to Tb4 and promotes cell migration. In combination, this experimentally validates TbNB as functional homologue of rat Tb15 in the human organism and clarifies the current composition of the human Tb family.