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Somatostatin inhibits insulin‐like growth factor‐I receptor expression in the gill of a teleost fish ( Oncorhynchus mykiss )
Author(s) -
Very Nicole M.,
Sheridan Mark A.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.08.079
Subject(s) - somatostatin , insulin like growth factor , receptor , biology , medicine , rainbow trout , endocrinology , in vitro , growth factor , gene isoform , in vivo , incubation , messenger rna , somatostatin receptor , chemistry , fish <actinopterygii> , biochemistry , gene , fishery , microbiology and biotechnology
Rainbow trout gill tissue was used to examine the role of somatostatin (SS) on insulin‐like growth factor‐I (IGF‐I) receptor expression. In vivo implantation of fish with somatostatin‐14 (SS‐14) reduced expression of IGF‐I receptor mRNAs as well as [ 125 I]‐IGF‐I binding. In vitro incubation of gill filaments with SS‐14 or various SS isoforms, including SS‐28 and [Tyr 7 , Gly 10 ]‐SS‐14‐containing peptides, directly inhibited IGF‐I receptor mRNA expression. SS‐14 also inhibited [ 125 I]‐IGF‐I binding in vitro. These data indicate that SSs inhibit the mRNA and functional expression of IGF‐I receptors in gill, and suggest that SSs regulate growth in an extrapituitary manner by reducing sensitivity to IGF‐I.