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Mouse Prickle1 and Prickle2 are expressed in postmitotic neurons and promote neurite outgrowth
Author(s) -
Okuda Hiroaki,
Miyata Shingo,
Mori Yasutake,
Tohyama Masaya
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.08.075
Subject(s) - neurite , gastrulation , microbiology and biotechnology , embryonic stem cell , biology , neuroscience , embryo , embryogenesis , gene , genetics , in vitro
The Drosophila planar cell polarity (PCP) gene prickle has been previously indicated as one of the regulators of gastrulation in the early embryonic stage. However, the functional role of prickle in the brain in particular is not known. We first indicated that mouse Prickle1 and Prickle2 are continually expressed in the brain throughout the embryonic stages and are observed to be specifically expressed in the postmitotic neurons. Furthermore, Prickle1 or Prickle2 depletion effectively decreases the neurite outgrowth levels of mouse neuroblastoma Neuro2a cells. These results indicate that mouse Prickle1 and Prickle2 possibly regulate positive neurite formation during brain development.