Premium
Mover is a novel vertebrate‐specific presynaptic protein with differential distribution at subsets of CNS synapses
Author(s) -
Kremer Thomas,
Kempf Christian,
Wittenmayer Nina,
Nawrotzki Ralph,
Kuner Thomas,
Kirsch Joachim,
Dresbach Thomas
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.08.070
Subject(s) - inhibitory postsynaptic potential , transmembrane protein , neuroscience , active zone , synapse , cerebellum , microbiology and biotechnology , mossy fiber (hippocampus) , biology , presynaptic inhibition , chemistry , hippocampus , synaptic vesicle , receptor , excitatory postsynaptic potential , biochemistry , membrane , vesicle , dentate gyrus
Presynaptic nerve terminals contain scaffolding proteins that orchestrate neurotransmitter release at active zones. Here we describe mover, a yet unknown non‐transmembrane protein that is targeted to presynaptic terminals when overexpressed in cultured neurons. Confocal immunomicroscopy revealed that mover colocalizes with presynaptic markers in the calyx of Held. In the hippocampus, mover localizes to mossy fibre terminals, but is absent from inhibitory nerve terminals. By contrast, mover localizes to inhibitory terminals throughout the cerebellar cortex. Our results suggest that mover may act in concert with generally expressed scaffolding proteins in distinct sets of presynaptic terminals.