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VEGF receptor Flk‐1 plays an important role in c‐kit expression in adipose tissue derived stem cells
Author(s) -
Bai Xiaowen,
Sadat Sanga,
Gehmert Sebastian,
Alt Eckhard,
Song Yao-Hua
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.08.063
Subject(s) - adipose tissue , stem cell , receptor , microbiology and biotechnology , biology , endocrinology , mapk/erk pathway , medicine , chemistry , signal transduction
It is known that c‐kit + cells are increased in heart after infarction. The exact origins of the cardiac c‐kit + cells remain to be determined. We asked whether adipose tissue could be a potential source of c‐kit + cells. Our data show that the number of c‐kit + cells increased in adipose tissue derived stem cells when cultured with conditioned medium from neonatal cardiomyocytes grown under serum deprivation and hypoxia condition. We also found that VEGF receptor Flk‐1 is involved in c‐kit up regulation via ERK‐mediated pathway.