Cytokinesis is not controlled by calmodulin or myosin light chain kinase in the  Caenorhabditis elegans  early embryo | Zendy

Batchelder Ellen L. | Zendy; Thomas-Virnig Christina L. | Zendy; Hardin Jeffery D. | Zendy; White John G. | Zendy

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Cytokinesis is not controlled by calmodulin or myosin light chain kinase in the Caenorhabditis elegans early embryo

Author(s) -

Batchelder Ellen L.,

Thomas-Virnig Christina L.,

Hardin Jeffery D.,

White John G.

Publication year - 2007

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2007.08.005

Subject(s) - cytokinesis , caenorhabditis elegans , myosin light chain kinase , microbiology and biotechnology , biology , calmodulin , myosin , ingression , phosphorylation , kinase , embryo , genetics , gastrulation , cell division , biochemistry , embryogenesis , gene , cell , enzyme

Furrow ingression in animal cell cytokinesis is controlled by phosphorylation of myosin II regulatory light chain (mRLC). In Caenorhabditis elegans embryos, Rho‐dependent Kinase (RhoK) is involved in, but not absolutely required for, this phosphorylation. The calmodulin effector myosin light chain kinase (MLCK) can also phosphorylate mRLC and is widely regarded as a candidate for redundant function with RhoK. However, our results show that RNA mediated interference against C. elegans calmodulin and candidate MLCKs had no effect on cytokinesis in wild‐type or RhoK mutant embryos, ruling out the calmodulin/MLCK pathway as the missing regulator of cytokinesis in the C. elegans early embryo.

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