Bim mediates mitochondria‐regulated particulate matter‐induced apoptosis in alveolar epithelial cells | Zendy

Zhang J. | Zendy; Ghio A.J. | Zendy; Chang W. | Zendy; Kamdar O. | Zendy; Rosen G.D. | Zendy; Upadhyay D. | Zendy

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Bim mediates mitochondria‐regulated particulate matter‐induced apoptosis in alveolar epithelial cells

Author(s) -

Zhang J.,

Ghio A.J.,

Chang W.,

Kamdar O.,

Rosen G.D.,

Upadhyay D.

Publication year - 2007

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2007.07.080

Subject(s) - apoptosis , microbiology and biotechnology , mitochondrion , downregulation and upregulation , chemistry , bcl 2 family , caspase , programmed cell death , biology , biochemistry , gene

We studied the role of Bim, a pro‐apoptotic BCL‐2 family member in Airborne particulate matter (PM 2.5 μm)‐induced apoptosis in alveolar epithelial cells (AEC). PM induced AEC apoptosis by causing significant reduction of mitochondrial membrane potential and increase in caspase‐9, caspase‐3 and PARP‐1 activation. PM upregulated pro‐apoptotic protein Bim and enhanced translocation of Bim to the mitochondria. ShRNABim blocked PM‐induced apoptosis by preventing activation of the mitochondrial death pathway suggesting a role of Bim in the regulation of mitochondrial pathway in AEC. Accordingly, we provide the evidence that Bim mediates PM‐induced apoptosis via mitochondrial pathway.

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