Main antimicrobial components of  Tinospora capillipes , and their mode of action against  Staphylococcus aureus | Zendy

Yu Yan | Zendy; Yi Zhi-biao | Zendy; Liang Yi-Zeng | Zendy

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Main antimicrobial components of Tinospora capillipes , and their mode of action against Staphylococcus aureus

Author(s) -

Yu Yan,

Yi Zhi-biao,

Liang Yi-Zeng

Publication year - 2007

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2007.07.056

Subject(s) - staphylococcus aureus , jatrorrhizine , palmatine , antimicrobial , norfloxacin , mode of action , chemistry , microbiology and biotechnology , antibiotics , rifampicin , cefalexin , high performance liquid chromatography , biology , chromatography , bacteria , biochemistry , ampicillin , ciprofloxacin , genetics

In this investigation, the antibacterial modes of action of Radix Tinosporae, its major single components, and nine antibiotics with different targets or modes‐of‐action on Staphylococcus aureus were studied. Metabolic profiles of cultures treated with different medicines were acquired by HPLC/ESI‐MS. After HPLC‐MS data pretreatment, those profiles acquired were reduced into several MS vectors. Then statistical processing by principal components analysis was carried out upon those vectors, two conclusions could be drawn: (1) the antibacterial mode of action of Radix Tinosporae is similar to that of rifampicin and norfloxacin, which act on nucleic acid; (2) its active components playing main antimicrobial roles on Staphylococcus aureus might be alkaloids, such as palmatine and jatrorrhizine.

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