Premium
CAMTAs: Calmodulin‐binding transcription activators from plants to human
Author(s) -
Finkler Aliza,
Ashery-Padan Ruth,
Fromm Hillel
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.07.051
Subject(s) - calmodulin , transcription factor , transcription (linguistics) , microbiology and biotechnology , activator (genetics) , biology , dna binding domain , dna binding protein , dna , general transcription factor , e box , binding domain , chemistry , binding site , genetics , promoter , biochemistry , gene , gene expression , enhancer , enzyme , linguistics , philosophy
Recently, a novel family of calmodulin‐binding transcription activators (CAMTAs) was reported in various eukaryotes. All CAMTAs share a similar domain organization, with a novel type of sequence‐specific DNA‐binding domain (designated CG‐1). This domain could bind DNA directly and activate transcription, or interact with other transcription factors, not through DNA binding, thus acting as a co‐activator of transcription. Investigations of CAMTAs in various organisms imply a broad range of functions from sensory mechanisms to embryo development and growth control, highlighted by the apparent involvement of mammalian CAMTA2 in cardiac growth, and of CAMTA1 in tumor suppression and memory performance.