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Identification of S6K2 as a centrosome‐located kinase
Author(s) -
Rossi Rossella,
Pester John M.,
McDowell Mitch,
Soza Samuela,
Montecucco Alessandra,
Lee-Fruman Kay K.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.07.047
Subject(s) - centrosome , microbiology and biotechnology , wortmannin , p70 s6 kinase 1 , pi3k/akt/mtor pathway , biology , signal transduction , cell cycle , cell , biochemistry
Ribosomal S6 kinase 2 (S6K2) acts downstream of the mammalian target of rapamycin (mTOR). Here, we show that some S6K2 localize at the centrosome throughout the cell cycle. S6K2 is found in the pericentriolar area of the centrosome. S6K2 centrosomal localization is unaffected by serum withdrawal or treatment with rapamycin, wortmannin, U0126, or phorbol‐12‐myristate‐13‐acetate (PMA). Unlike S6K2, S6 kinase 1 (S6K1) does not localize at the centrosome, suggesting the two kinases may also have nonoverlapping functions. Our data suggest that centrosomal S6K2 may have a role in the phosphoinositide‐3‐kinase (PI3K)/Akt/mTOR signaling pathway that has also been detected in the centrosome.