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An arachidonic acid generation/export system involved in the regulation of cholesterol transport in mitochondria of steroidogenic cells
Author(s) -
Duarte Alejandra,
Castillo Ana Fernanda,
Castilla Rocío,
Maloberti Paula,
Paz Cristina,
Podestá Ernesto J.,
Cornejo Maciel Fabiana
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.07.040
Subject(s) - mitochondrion , steroidogenic acute regulatory protein , arachidonic acid , cholesterol side chain cleavage enzyme , biochemistry , inner mitochondrial membrane , microbiology and biotechnology , adenosine monophosphate , fatty acid , chemistry , adenosine , biology , metabolism , enzyme , gene expression , gene , cytochrome p450
Recent studies demonstrated the importance of the mitochondrial ATP in the regulation of a novel long‐chain fatty acid generation/export system in mitochondria of diabetic rat heart. In steroidogenic systems, mitochondrial ATP and intramitochondrial arachidonic acid (AA) generation are important for steroidogenesis. Here, we report that mitochondrial ATP is necessary for the generation and export of AA, steroid production and steroidogenic acute regulatory protein induction supported by cyclic 3′–5′‐adenosine monophosphate in steroidogenic cells. These results demonstrate that ATP depletion affects AA export and provide new evidence of the existence of the fatty acid generation and export system involved in mitochondrial cholesterol transport.