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Palmitoylcarnitine regulates estrification of lipids and promotes palmitoylation of GAP‐43
Author(s) -
Nałęcz Katarzyna A.,
Szczepankowska Dorota,
Czeredys Magdalena,
Kulikova Natalia,
Grześkiewicz Stanisław
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.07.027
Subject(s) - palmitoylcarnitine , palmitoylation , palmitic acid , biochemistry , phosphorylation , microbiology and biotechnology , chemistry , signal transduction , biology , fatty acid , carnitine , enzyme , cysteine
Palmitoylcarnitine was previously shown to promote differentiation of neuroblastoma NB‐2a cells. It was also observed to increase palmitoylation of several proteins and to diminish incorporation of palmitic acid to phospholipids, as well as to affect growth associated protein GAP‐43 by decreasing its phosphorylation and interaction with protein kinase C. The present study was focused on influence of palmitoylcarnitine on palmitoylation of GAP‐43 and lipid metabolism. Althought palmitoylcarnitine did not significantly affect the total phospholipids and fatty acid content, it increased incorporation of palmitate moiety to triacylglicerides and cholesterol esters, with a decrease of free cholesterol content. The presence of palmitoylcarnitine significantly increased the amount of covalently bound palmitate to GAP‐43, which can regulate the signal transduction pathways.