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Xyr1 receives the lactose induction signal and regulates lactose metabolism in Hypocrea jecorina
Author(s) -
Stricker Astrid R.,
Steiger Matthias G.,
Mach Robert L.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.07.025
Subject(s) - hypocrea , lac repressor , catabolite repression , transcription (linguistics) , xylanase , biochemistry , lactose , chemistry , transcription factor , microbiology and biotechnology , biology , repressor , enzyme , trichoderma reesei , gene , linguistics , philosophy , mutant , cellulase
This study reports the vital regulatory influence of Xyr1 (xylanase regulator 1) on the transcription of hydrolytic enzyme‐encoding genes and hydrolase formation on lactose in Hypocrea jecorina . While the transcription of the xyr1 gene itself is achieved by release of carbon catabolite repression, the transcript formation of xyn1 (xylanase 1) is regulated by an additional induction mechanism mediated by lactose. Xyr1 has an important impact on lactose metabolism by directly activating xyl1 (xylose reductase 1) transcription and indirectly influencing transcription of bga1 (β‐galactosidase 1). The latter is achieved by regulating the conversion of d ‐galactose to the inducing carbon source galactitol.