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Do mitochondria act as “cargo boats” in the journey of GD3 to the nucleus during apoptosis?
Author(s) -
Garofalo Tina,
Tinari Antonella,
Matarrese Paola,
Giammarioli Anna Maria,
Manganelli Valeria,
Ciarlo Laura,
Misasi Roberta,
Sorice Maurizio,
Malorni Walter
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.07.020
Subject(s) - microbiology and biotechnology , mitochondrion , organelle , apoptosis , fas receptor , lipid raft , cytochrome c , mitochondrial fission , biology , chemistry , signal transduction , programmed cell death , biochemistry
Plasma membrane lipid rafts have been considered as a sort of “chamber”, where several subcellular activities, including CD95/Fas‐mediated pro‐apoptotic signaling, can take place. Recently, we demonstrated that, after CD95/Fas triggering, raft‐like microdomains could be detected in mitochondrial membranes. The mitochondrion appears as a dynamic and subcompartmentalized organelle in which microdomains might act as controllers of apoptosis‐associated fission that results in the release of apoptogenic factors. Here, we hypothesize that some “small” mitochondria, possibly derived from their fission process, can reach the nuclear envelope and strictly interact with this. Mitochondria could act as a signaling “device” contributing to molecular trafficking of molecules, including raft‐like components, during apoptosis.