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Novel clusters of highly expressed genes accompany genomic amplification in breast cancers
Author(s) -
Ito Emi,
Honma Reiko,
Yanagisawa Yuka,
Imai Jun-ichi,
Azuma Sakura,
Oyama Tetsunari,
Ohwada Susumu,
Akiyama Tetsu,
Nomura Nobuo,
Inoue Jun-ichiro,
Watanabe Shinya,
Semba Kentaro
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.07.016
Subject(s) - amplicon , carcinogenesis , breast cancer , biology , gene , cancer , gene duplication , phenotype , genetics , cancer research , computational biology , microbiology and biotechnology , polymerase chain reaction
Breast cancer is the most common cancer in women worldwide. To identify novel amplicons involved in the mammary carcinogenesis, we constructed gene expression maps of chromosomes in 35 human breast cancer cell lines and extracted six candidate amplicons containing highly expressed gene clusters on chromosomes 8, 17, and X. We also confirmed the presence of the identified amplicons in clinical specimens by Southern blot analysis. Highly expressed genes identified in the amplicons will contribute to the characterization of breast cancer phenotypes, thereby providing novel targets for anticancer therapies.