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Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis
Author(s) -
Roy Hemant K.,
Wali Ramesh K.,
Kim Young,
Liu Yang,
Hart John,
Kunte Dhananjay P.,
Koetsier Jennifer L.,
Goldberg Michael J.,
Backman Vadim
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.07.012
Subject(s) - azoxymethane , nitric oxide , nitric oxide synthase , carcinogenesis , carcinogen , blood supply , colorectal cancer , chemistry , pathology , medicine , endocrinology , cancer research , biochemistry , cancer , surgery
We have recently demonstrated that dramatic alteration in mucosal microvascular blood content termed early increase in blood supply (EIBS) is a hallmark of early colon carcinogenesis. In the current study, we elucidate the mechanism of EIBS by assessing iNOS/nitric oxide axis in the histologically normal colonic mucosa of rats treated with the colon‐specific carcinogen, azoxymethane. We demonstrate that there was a strong temporal correlation between EIBS and iNOS expression/activity. Importantly, we also observed that short‐term treatment with nitric oxide inhibitor abrogated EIBS. These data indicate that iNOS induction may have a critical role in augmenting the predysplastic mucosal blood supply and thereby fostering colon carcinogenesis.