Indole‐3‐carbinol – Induced growth inhibition can be converted to a cytotoxic response in the presence of TPA + Ca 2+  in squamous cell carcinoma cell lines | Zendy

Dahler A.L. | Zendy; Rickwood D. | Zendy; Guminski A. | Zendy; Teakle N. | Zendy; Saunders N.A. | Zendy

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Indole‐3‐carbinol – Induced growth inhibition can be converted to a cytotoxic response in the presence of TPA + Ca 2+ in squamous cell carcinoma cell lines

Author(s) -

Dahler A.L.,

Rickwood D.,

Guminski A.,

Teakle N.,

Saunders N.A.

Publication year - 2007

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2007.07.009

Subject(s) - cytotoxic t cell , growth inhibition , cytotoxicity , cell culture , cancer research , chemistry , cell growth , stimulus (psychology) , activator (genetics) , squamous carcinoma , cellular differentiation , microbiology and biotechnology , biology , medicine , biochemistry , in vitro , carcinoma , receptor , gene , psychology , genetics , psychotherapist

We examined the possibility that I3C, when combined with a differentiation stimulus (TPA + CaCl 2 ), would sensitise SCC cells to a differentiation stimulus. We report that I3C induces a profound growth inhibition in SCC cells that is dissimilar to the growth inhibition required to initiate differentiation. Moreover, we report that I3C, when combined with TPA + CaCl 2 treatment, induces a loss of colony forming ability that was differentiation and senescence – independent but was due to delayed cytotoxicity. This study shows that I3C in combination with a PKC activator + Ca 2+ may be a useful therapeutic strategy for treating oral SCC.

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