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Sleep and circadian rhythms: Key components in the regulation of energy metabolism
Author(s) -
Laposky Aaron D.,
Bass Joseph,
Kohsaka Akira,
Turek Fred W.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.06.079
Subject(s) - circadian rhythm , sleep (system call) , energy metabolism , neuroscience , disease , circadian clock , biology , obesity , cognitive science , psychology , medicine , endocrinology , computer science , operating system
In this review, we present evidence from human and animal studies to evaluate the hypothesis that sleep and circadian rhythms have direct impacts on energy metabolism, and represent important mechanisms underlying the major health epidemics of obesity and diabetes. The first part of this review will focus on studies that support the idea that sleep loss and obesity are “interacting epidemics.” The second part will discuss recent evidence that the circadian clock system plays a fundamental role in energy metabolism at both the behavioral and molecular levels. These lines of research must be seen as in their infancy, but nevertheless, have provided a conceptual and experimental framework that potentially has great importance for understanding metabolic health and disease.