Premium
Chronic lung inflammation in aging mice
Author(s) -
Aoshiba Kazutetsu,
Nagai Atsushi
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.06.075
Subject(s) - inflammation , provirus , biology , downregulation and upregulation , immunology , reverse transcription polymerase chain reaction , lung , cd8 , cd20 , pathology , lymphoma , gene expression , microbiology and biotechnology , gene , medicine , immune system , biochemistry , genome
To determine whether aging is associated with a pro‐inflammatory shift in the lung, inflammation and inflammation‐related gene expression in the lungs of 12‐week‐old and 24‐month‐old Balb/c mice were studied. cDNA microarray and quantitative reverse transcription‐polymerase chain reaction analyses showed that eight inflammation‐related genes, including CD20, Burkitt lymphoma receptor 1, CXCR‐3, provirus integration site for Moloney murine leukemia virus‐2, CD72, IL‐8RB, C‐Fgr, and CD8β, were upregulated in the aged mice. Immunohistochemistry showed that the lungs of the aged mice contained increased numbers of CD4 cells, CD8 cells, B cells and macrophages. These results suggest that a pro‐inflammatory shift occurs in the lungs of mice with aging.