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CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair
Author(s) -
Lax Siân,
Hou Tie Zheng,
Jenkinson Eric,
Salmon Mike,
MacFadyen John R.,
Isacke Clare M.,
Anderson Graham,
Cunningham Adam F.,
Buckley Christopher D.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.06.063
Subject(s) - stromal cell , tissue remodeling , lymphatic system , microbiology and biotechnology , biology , pathology , cancer research , immunology , medicine , inflammation
Studies of stromal cell populations in lymphoid tissue (LT) have been hampered by a lack of selective markers. Here, we show that CD248 (Endosialin/TEM1) is a stromal marker that is differentially expressed on fibroblasts and pericytes in the thymus, lymph node and spleen. Expression is high during LT development but largely disappears in the adult. CD248 is re‐expressed in a Salmonella ‐induced model of splenic enlargement; peak expression corresponding to the peak of splenic enlargement. These results suggest that CD248 expression helps define a subset of LT stromal cells which play a role in remodelling during tissue development, infection and repair.