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B cell terminal differentiation factor XBP‐1 induces reactivation of Kaposi's sarcoma‐associated herpesvirus
Author(s) -
Yu Fuqu,
Feng Jiaying,
Harada Josephine N.,
Chanda Sumit K.,
Kenney Shan C.,
Sun Ren
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.06.056
Subject(s) - lytic cycle , kaposi's sarcoma associated herpesvirus , biology , microbiology and biotechnology , transcription factor , activator (genetics) , viral replication , virology , transcription (linguistics) , cell , virus , herpesviridae , gene , genetics , viral disease , linguistics , philosophy
The herpesvirus life cycle has two distinct phases: latency and lytic replication. The viral immediate early protein replication and transcription activator (RTA) plays a central role in mediating the balance between these two phases. Here, we demonstrate that a B cell terminal differentiation factor X‐box binding protein 1 (XBP‐1) can effectively initiates Kaposi's sarcoma‐associated herpesvirus (KSHV) reactivation by activating the RTA promoter, which results in the induction of other viral lytic transcripts. We also showed splicing of the XBP‐1 mRNA which specifically occurs during B cell differentiation is critical in triggering KSHV reactivation. This work demonstrates the integration of KSHV reactivation mechanisms with host cell differentiation.