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RNA‐binding protein Csx1 is phosphorylated by LAMMER kinase, Lkh1, in response to oxidative stress in Schizosaccharomyces pombe
Author(s) -
Kang Won-Hwa,
Park Yoon-Dong,
Hwang Ji-Sook,
Park Hee-Moon
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.06.053
Subject(s) - schizosaccharomyces pombe , schizosaccharomyces , oxidative stress , cyclin dependent kinase 7 , kinase , oxidative phosphorylation , protein kinase a , biochemistry , microbiology and biotechnology , yeast , biology , chemistry , map kinase kinase kinase , saccharomyces cerevisiae
Recent studies have shown that global gene expression during oxidative stress in Schizosaccharomyces pombe is regulated by stress‐induced activation and binding of Csx1 to atf1 + mRNA. However, the kinase responsible for the activation of Csx1 has not been identified. Here, we describe, for the first time, that Csx1 is phosphorylated by S. pombe LAMMER kinase, Lkh1, under oxidative conditions and that the stress‐activated binding of the Csx1 to the atf1 + mRNA was also affected by Lkh1 and Spc1. These data indicate that concerted actions of Spc1 and Lkh1 are required for the activation of Csx1 during oxidative condition in the fission yeast S. pombe .