Premium
Clusterin is associated with spontaneous breast cancer in TA2 mice
Author(s) -
Sun Baocun,
Zhang Shiwu,
Zhang Danfang,
Liu Yanqing,
Li Yan,
Rong Zhe,
Zhu Yue,
Jia Xinghong
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.06.021
Subject(s) - clusterin , breast cancer , cancer research , cancer , medicine , oncology , biology , apoptosis , genetics
Two‐dimensional electrophoresis and Matrix‐assisted laser desorption ionization‐time of flight‐time of mass spectrometry were used to detect the differentially expressed proteins in serum of tientsin albinao 2 mice with spontaneous breast cancer, normal tientsin albinao 2 mice and tientsin albinao 1 mice. Only nuclear clusterin (n‐CLU) was expressed in tientsin albinao 1. Immunohistochemistry and western blot validated that n‐CLU was present in normal tientsin albinao 2 and tientsin albinao 1 mammary epithelium, and secretory clusterin expressed in the cytoplasm of normal tientsin albinao 2 mammary epithelium and spontaneous breast cancer. n‐CLU may play an important role in tientsin albinao 2 spontaneous breast cancer initiation and development.