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The maximal size of protein to diffuse through the nuclear pore is larger than 60 kDa
Author(s) -
Wang Ruiwen,
Brattain Michael G.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.05.082
Subject(s) - nuclear pore , diffusion , limit (mathematics) , chemistry , nuclear protein , chemical physics , biophysics , physics , biochemistry , biology , thermodynamics , mathematics , mathematical analysis , cytoplasm , gene , transcription factor
It has generally been believed that the diffusion limit set by the nuclear pore for protein is 60 kDa. We here studied the cellular localization of several artificial proteins and found that the diffusion limit set by the nuclear pore is not as small as previously thought. The results indicate that the maximal size of protein to diffuse through the nuclear pore complex could be quite larger than 60 kDa, thus greatly extending the diffusion limit that the nuclear pore can accommodate.