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Isolation and characterization of nudC from mouse macrophages, a gene implicated in the inflammatory response through the regulation of PAF‐AH(I) activity
Author(s) -
Riera José,
Rodríguez René,
Carcedo María Teresa,
Campa Víctor M.,
Ramos Sofía,
Lazo Pedro S.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.05.065
Subject(s) - gene , function (biology) , complementary dna , peptide sequence , protein subunit , biology , cloning (programming) , microbiology and biotechnology , genetics , computer science , programming language
We report the characterization of a cDNA induced in mouse macrophages that encodes a 332‐amino acid protein with extensive sequence identity with members of the mammalian nudC ‐like genes. The interaction between mNUDC and the regulatory β subunit of platelet activating factor acetylhydrolase I (PAF‐AH(I)) shown in this article indicates a new function of NUDC. Thus, we show that NUDC increases the catalytic activity of PAF‐AH(I) and that this regulatory activity is located in the carboxyl terminal half of the protein which is highly conserved. This suggests a novel function for mammalian nudC ‐like genes as anti‐inflammatory proteins.