Impairment in a negative regulatory system for TCR signaling in CD4 +  T cells from old mice | Zendy

Inomata Mitsushi | Zendy; Shimada Yukiko | Zendy; Hayashi Masami | Zendy; Shimizu Jun | Zendy; Ohno-Iwashita Yoshiko | Zendy

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Impairment in a negative regulatory system for TCR signaling in CD4 + T cells from old mice

Author(s) -

Inomata Mitsushi,

Shimada Yukiko,

Hayashi Masami,

Shimizu Jun,

Ohno-Iwashita Yoshiko

Publication year - 2007

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2007.05.063

Subject(s) - lipid raft , regulator , microbiology and biotechnology , kinase , phosphorylation , biology , t cell receptor , signal transduction , src family kinase , negative regulator , proto oncogene tyrosine protein kinase src , chemistry , endocrinology , t cell , immunology , biochemistry , gene , immune system

To examine the involvement of lipid rafts in an age‐associated decline in T cell function, we analyzed the effect of aging on the constituents of lipid rafts in resting mouse CD4 + T cells. We found a pronounced, age‐dependent reduction in PAG/Cbp, which is involved in the regulation of Src family kinases (SFKs) by recruiting Csk (a negative regulator of SFKs) to lipid rafts. This reduction is specific for T cells and is attributed, at least in part, to the reduction in its mRNA level. The reduction of PAG accompanies marked impairment in recruiting Csk to lipid rafts and a concomitant decrease in the inactive forms of SFKs. These findings indicate that old mouse CD4 + T cells have a defect in a negative SFK regulatory system.

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