DNA photodamage recognition by RNA polymerase II | Zendy

Brueckner Florian | Zendy; Cramer Patrick | Zendy

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DNA photodamage recognition by RNA polymerase II

Author(s) -

Brueckner Florian,

Cramer Patrick

Publication year - 2007

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2007.05.014

Subject(s) - rna polymerase ii , transcription (linguistics) , dna polymerase , microbiology and biotechnology , dna polymerase ii , dna , polymerase , dna clamp , biology , transcription bubble , chemistry , gene , rna , genetics , rna dependent rna polymerase , reverse transcriptase , gene expression , promoter , linguistics , philosophy

During gene transcription, RNA polymerase (Pol) II encounters obstacles, including lesions in the DNA template. Here, we review a recent structure–function analysis of Pol II transcribing DNA with a bulky photo‐lesion in the template strand. The study provided the molecular basis for recognition of a damaged DNA by Pol II, which is the first step in transcription‐coupled DNA repair (TCR). The results have general implications for damage recognition and the TCR mechanism.

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