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DNA photodamage recognition by RNA polymerase II
Author(s) -
Brueckner Florian,
Cramer Patrick
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.05.014
Subject(s) - rna polymerase ii , transcription (linguistics) , dna polymerase , microbiology and biotechnology , dna , polymerase , dna polymerase ii , t cell receptor , dna clamp , biology , chemistry , gene , rna , genetics , reverse transcriptase , gene expression , promoter , t cell , linguistics , philosophy , immune system
During gene transcription, RNA polymerase (Pol) II encounters obstacles, including lesions in the DNA template. Here, we review a recent structure–function analysis of Pol II transcribing DNA with a bulky photo‐lesion in the template strand. The study provided the molecular basis for recognition of a damaged DNA by Pol II, which is the first step in transcription‐coupled DNA repair (TCR). The results have general implications for damage recognition and the TCR mechanism.