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The Ndc80 complex: Hub of kinetochore activity
Author(s) -
Ciferri Claudio,
Musacchio Andrea,
Petrovic Arsen
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.05.012
Subject(s) - kinetochore , microbiology and biotechnology , sister chromatids , chromosome segregation , spindle checkpoint , spindle apparatus , microtubule , biology , mitosis , cohesin , chemistry , genetics , meiosis , chromosome , cell division , cell , gene
Kinetochores are protein scaffolds coordinating the process of chromosome segregation in mitosis. Kinetochore components are organized in functionally and topologically distinct domains that are designed to connect the sister chromatids to the mitotic spindle. The inner kinetochore proteins are in direct contact with the centromeric DNA, whilst the outer kinetochore proteins are responsible for binding to spindle microtubules. The conserved Ndc80 complex is implicated in several essential outer kinetochore functions, including microtubule binding and control of a safety device known as the spindle assembly checkpoint. Here, we describe how current work is contributing to unravel the complex endeavors of this essential kinetochore complex.