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Identification and characterization of DUSP27, a novel dual‐specific protein phosphatase
Author(s) -
Friedberg Ilan,
Nika Konstantina,
Tautz Lutz,
Saito Kan,
Cerignoli Fabio,
Friedberg Iddo,
Godzik Adam,
Mustelin Tomas
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.04.059
Subject(s) - gene , exon , biology , gene duplication , microbiology and biotechnology , enzyme , skeletal muscle , amino acid , adipose tissue , cytosol , biochemistry , endocrinology
A novel human dual‐specific protein phosphatase (DSP), designated DUSP27, is here described. The DUSP27 gene contains three exons, rather than the predicted 4–14 exons, and encodes a 220 amino acid protein. DUSP27 is structurally similar to other small DSPs, like VHR and DUSP13. The location of DUSP27 on chromosome 10q22, 50 kb upstream of DUSP13 , suggests that these two genes arose by gene duplication. DUSP27 is an active enzyme, and its kinetic parameters and were determined. DUSP27 is a cytosolic enzyme, expressed in skeletal muscle, liver and adipose tissue, suggesting its possible role in energy metabolism.