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The lipid peroxidation end‐product 4‐HNE induces COX‐2 expression through p38MAPK activation in 3T3‐L1 adipose cell
Author(s) -
Zarrouki B.,
Soares A.F.,
Guichardant M.,
Lagarde M.,
Géloën A.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.04.048
Subject(s) - 4 hydroxynonenal , lipid peroxidation , oxidative stress , chemistry , inflammation , adipose tissue , 3t3 l1 , oxidative phosphorylation , nadph oxidase , cyclooxygenase , medicine , endocrinology , biochemistry , biology , enzyme , adipocyte
Our results show that oxidative stress induces COX‐2 expression through the production of 4‐HNE which activates p38MAPKinase, suggesting that 4‐HNE links oxidative stress and chronic inflammation through the activation of cyclooxygenase.