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Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats
Author(s) -
Tikoo Kulbhushan,
Bhatt Deepak Kumar,
Gaikwad Anil Bhanudas,
Sharma Vikram,
Kabra Dhiraj G.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.04.036
Subject(s) - tannic acid , nephrotoxicity , cisplatin , chemistry , pharmacology , biochemistry , toxicity , chemotherapy , medicine , organic chemistry
Cisplatin is a widely used antineoplastic drug. Major drawback of cisplatin therapy is its nephrotoxicity. The objective of this study was to check the effect of tannic acid on cisplatin induced nephrotoxicity. Post‐treatment of tannic acid prevents cisplatin (5 mg/kg) induced nephrotoxicity and decreases poly(ADP‐ribose) polymerase cleavage, phosphorylation of p38 and hypoacetylation of histone H4. In contrast, co‐treatment of tannic acid potentiates the nephrotoxicity. Comparative nephrotoxicity studies show that co‐treatment of tannic acid with reduced dose of cisplatin (1.5 mg/kg) developed almost similar nephrotoxicity. MALDI protein profiling of plasma samples provides indirect evidence that tannic acid co‐treatment increases bioavailability of cisplatin.