Premium
Anti‐cytokine autoantibodies are ubiquitous in healthy individuals
Author(s) -
Watanabe Masato,
Uchida Kanji,
Nakagaki Kazuhide,
Kanazawa Hiroko,
Trapnell Bruce C.,
Hoshino Yoshihiko,
Kagamu Hiroshi,
Yoshizawa Hirohisa,
Keicho Naoto,
Goto Hajime,
Nakata Koh
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.04.029
Subject(s) - autoantibody , cytokine , immunology , tumor necrosis factor alpha , osteopontin , medicine , biology , antibody
Anti‐cytokine autoantibodies in healthy individuals have been widely reported but the occurrence is variable and inconstant. We hypothesized that cytokine‐binding in vivo may explain their variable and infrequent detection. Therefore, we focused on the detection of the cytokine‐autoantibody complexes and found that anti‐cytokine autoantibody to IL‐2, IL‐8, tumor necrosis factor‐α, vascular endothelial growth factor and granulocyte‐colony stimulating factor were present in all 15 individuals evaluated, while those to IL‐3, osteopontin and macrophage‐colony stimulating factor were not detected in anyone. Autoantibodies against IL‐4, IL‐6, IL‐10, and interferon‐gamma were variously detected. Thus, we discovered that anti‐cytokine autoantibodies to multiple cytokines are ubiquitous in healthy individuals.