Premium
Triphlorethol‐A induces heme oxygenase‐1 via activation of ERK and NF‐E2 related factor 2 transcription factor
Author(s) -
Kang Kyoung Ah,
Lee Kyoung Hwa,
Park Jae Woo,
Lee Nam Ho,
Na Hye Kyung,
Surh Young Joon,
You Ho Jin,
Chung Myung Hee,
Hyun Jin Won
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.04.022
Subject(s) - heme oxygenase , mapk/erk pathway , transcription factor , heme , oxidative stress , kinase , microbiology and biotechnology , chemistry , signal transduction , nf κb , protein kinase a , biology , biochemistry , enzyme , gene
Triphlorethol‐A, phlorotannin found in Ecklonia cava , induced heme oxygenase‐1 (HO‐1) expression at mRNA and protein levels, leading to increased HO‐1 activity. Transcription factor NF‐E2 related factor 2 (Nrf2) regulates antioxidant response element (ARE) of phase 2 detoxifying and antioxidant enzymes. Triphlorethol‐A increased nuclear translocation, ARE binding, and transcriptional activity of Nrf2. Triphlorethol‐A exhibited activation of ERK and U0126, inhibitor of ERK kinase, suppressed triphlorethol‐A induced activation of Nrf2, finally decreased HO‐1 protein level. Taken together, these data suggest that triphlorethol‐A augments cellular antioxidant defense capacity through induction of HO‐1 via ERK‐Nrf2‐ARE signaling pathway, thereby protecting cells from oxidative stress.