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Somatostatin induces rapid contraction of neuroendocrine cells
Author(s) -
Saras Jan,
Grönberg Malin,
Stridsberg Mats,
Öberg Kjell E.,
Janson Eva T.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.04.019
Subject(s) - somatostatin , forskolin , chromogranin a , contraction (grammar) , delta cell , medicine , endocrinology , chemistry , peptide hormone , microbiology and biotechnology , biology , hormone , immunohistochemistry , stimulation , glucagon
The peptide hormone somatostatin, as well as the somatostatin analog octreotide, induces rapid morphological changes in neuroendocrine cells. The effect can be detected in less than 2 min: retraction fibers are formed, cells round up and cell–cell contacts are broken. Somatostatin‐dependent cell contraction is inhibited by Y‐27632, indicating that this effect is dependent on Rho kinase. In BON1 cells, the somatostatin‐induced inhibition of forskolin‐induced secretion of chromogranin A is not blocked by Y‐27632. It is therefore concluded that the inhibitory effect of somatostatin in forskolin‐stimulated cells is not dependent on cell contraction.