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Extensive selection for the enrichment of G4 DNA motifs in transcriptional regulatory regions of warm blooded animals
Author(s) -
Zhao Yiqiang,
Du Zhuo,
Li Ning
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.04.017
Subject(s) - biology , gene , genetics , regulatory sequence , dna , transcription factor , transcription (linguistics) , transcriptional regulation , regulation of gene expression , computational biology , linguistics , philosophy
A comprehensive analysis of potential G4 DNA motifs (G4Ms) in genomic regions flanking transcription start sites (TSS) was performed across 13 animal species. We found that G4Ms are significantly enriched in the transcriptional regulatory regions (TRRs) of warm‐blooded animals. Further analysis of human genes in different temporal groups reveals that the enrichment is not specific to genes found only in warm‐blooded species but instead exist in a wide range of genes. Our findings therefore suggest that the high prevalence of G4Ms in TRRs is extensively selected in warm‐blooded animals, supporting the hypothesis that G4Ms are involved in the regulation of gene transcription.