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Crosstalk between xenobiotics metabolism and circadian clock
Author(s) -
Claudel Thierry,
Cretenet Gaspard,
Saumet Anne,
Gachon Frédéric
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.04.009
Subject(s) - circadian rhythm , circadian clock , crosstalk , biology , entrainment (biomusicology) , xenobiotic , cryptochrome , bacterial circadian rhythms , clock , microbiology and biotechnology , physiology , neuroscience , biochemistry , rhythm , medicine , enzyme , optics , physics
Many aspects of physiology and behavior in organisms from bacteria to man are subjected to circadian regulation. Indeed, the major function of the circadian clock consists in the adaptation of physiology to daily environmental change and the accompanying stresses such as exposition to UV‐light and food‐contained toxic compounds. In this way, most aspects of xenobiotic detoxification are subjected to circadian regulation. These phenomena are now considered as the molecular basis for the time‐dependence of drug toxicities and efficacy. However, there is now evidences that these toxic compounds can, in turn, regulate circadian gene expression and thus influence circadian rhythms. As food seems to be the major regulator of peripheral clock, the possibility that food‐contained toxic compounds participate in the entrainment of the clock will be discussed.