Premium
Gene expression signatures in the newt irises during lens regeneration
Author(s) -
Makarev Evgeny,
Call Mindy K.,
Grogg Matthew W.,
Atkinson Donald L.,
Milash Brett,
Odelberg Shan J.,
Tsonis Panagiotis A.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.03.082
Subject(s) - transdifferentiation , iris (biosensor) , regeneration (biology) , biology , lens (geology) , dorsum , microbiology and biotechnology , anatomy , gene expression , gene , genetics , stem cell , paleontology , computer security , computer science , biometrics
Lens regeneration in adult newts is possible by transdifferentiation of the pigment epithelial cells (PECs) of the dorsal iris. The same cells in the ventral iris are not capable of such a process. To understand this difference in regenerative competency, we examined gene expression of 373 genes in the intact dorsal and ventral irises as well as in irises during the process of lens regeneration. We found similar signatures of gene expression in dorsal and ventral with several cases of even higher levels in the ventral iris. Such transcriptional activity in the regeneration‐incompetent ventral iris was unexpected and calls for a revision of our views about mechanisms of lens regeneration induction.