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Stress molecules in sepsis and systemic inflammatory response syndrome
Author(s) -
Adib-Conquy Minou,
Cavaillon Jean-Marc
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.03.074
Subject(s) - sepsis , systemic inflammatory response syndrome , immunology , inflammation , endogeny , organ dysfunction , systemic inflammation , receptor , pathogen , inflammatory response , host response , pattern recognition receptor , biology , medicine , microbiology and biotechnology , immune system , innate immune system , genetics , endocrinology
During sepsis, microbial derived products (“pathogen‐associated molecular patterns”, PAMPs) are recognized as exogenous danger signals by specific sensors of the host (“pattern recognitions receptors”, PRRs). This interaction leads to the release of numerous stress proteins that are a prerequisite to fight infection, though their overzealous production can contribute to tissue damage, organ dysfunction and eventually death. In critically ill patients, translocation of PAMPs can occur from the gut, and injured tissues and cells release endogenous danger signals called “alarmins” (e.g. High mobility group box‐1); that share some properties with PAMPs. Thus, numerous similarities occur during infectious and non‐infectious systemic inflammation.