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Up‐regulation of the Ku heterodimer in Drosophila testicular cyst cells
Author(s) -
Boutanaev Alexander M.,
Mikhaylova Lyudmila M.,
Nurminsky Dmitry I.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.03.042
Subject(s) - germline , somatic cell , biology , cyst , microbiology and biotechnology , spermatogenesis , cytoplasm , sperm , gene , germ cell , genetics , pathology , endocrinology , medicine
In Drosophila , developing germline cysts in testis are enveloped by two somatic cyst cells essential for germline development and male reproduction. The cyst cells continue development along with the germline. However, the mechanisms of somatic gene expression in testes are poorly understood. We report transcriptional up‐regulation of the Ku heterodimer in cyst cells. The initial up‐regulation is independent of germline, and transcription is further augmented during spermatogenesis. Abundance of Ku in the cyst cell cytoplasm suggests the role for Ku subunits in the regulation of sperm individualization.