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Epigenetic up‐regulation of CXCR4 and CXCL12 expression by 17 β‐estradiol and tamoxifen is associated with formation of DNA methyltransferase 3B4 splice variant in Ishikawa endometrial adenocarcinoma cells
Author(s) -
Kubarek Ł.,
Jagodzinski P.P.
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.02.070
Subject(s) - dna methylation , cancer research , demethylating agent , biology , tamoxifen , estrogen receptor , endometrial cancer , stromal cell , dna methyltransferase , methyltransferase , epigenetics , microbiology and biotechnology , methylation , cancer , gene expression , breast cancer , gene , biochemistry , genetics
Our results suggest that E2 and Tam, through their ability for gene‐transcription regulation, change the cellular milieu that maintains the hypermethylated stage of CpG islands of CXCR4 and CXCL12 promoters.