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Effects of tau phosphorylation on proteasome activity
Author(s) -
Ren Qing-Guo,
Liao Xiao-Mei,
Chen Xiao-Qian,
Liu Gong-Ping,
Wang Jian-Zhi
Publication year - 2007
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2007.02.065
Subject(s) - lactacystin , proteasome , phosphorylation , hyperphosphorylation , microbiology and biotechnology , tau protein , chemistry , protease , proteasome inhibitor , biochemistry , biology , alzheimer's disease , enzyme , medicine , disease
Dysfunction of proteasome contributes to the accumulation of the abnormally hyperphosphorylated tau in Alzheimer's disease. However, whether tau hyperphosphorylation and accumulation affect the activity of proteasome is elusive. Here we found that a moderate tau phosphorylation activated the trypsin‐like activity of proteasome, whereas further phosphorylation of tau inhibited the activity of the protease in HEK293 cells stably expressing tau441. Furthermore, tau hyperphosphorylation could partially reverse lactacystin‐induced inhibition of proteasome. These results suggest that phosphorylation of tau plays a dual role in modulating the activity of proteasome.